Word: drawbacking
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Although Hyman and Rawlins hope for a change in council demographics, one potential drawback is the loss of the many councillors who will not run for re-election...
Useful as they are, these drugs share the same serious drawback. Because they target all dividing cells, they also kill off normal tissue in the skin, hair and bone marrow. The next generation of anticancer agents, however, promises to be much more selective. By targeting oncogenes, for example, researchers hope to switch off the signals that prompt cancer cells to divide in the first place. Particularly promising is a class of drugs known as farnesyltransferase inhibitors, which have been shown to shrink tumors while sparing normal tissues. "Oncology is not a profession that inspires optimism," admits Dr. Allen Oliff, director...
...affinity for serotonin receptors, Clozaril is largely free of the Parkinsonian side effects (the "Thorazine shuffle" and so on) that plague the classic antipsychotic drugs. It was also the first drug to ameliorate symptoms of schizophrenia that are resistant to other drugs. But Clozaril has a major drawback: a life-threatening side effect called agranulocytosis, a drastic drop in white blood cells that requires patients to undergo expensive weekly blood monitoring...
...only drawback of the team's encouraging analysis was that Yeltsin took it too much to heart. "When he said he was confident that he'd win the election outright in the first round by capturing 50% of the vote, it told us again that you can only lead politicians so far," says Dresner. "The only real threat to victory was a low turnout, and Yeltsin helped depress it by giving voters a reason to take the day off. If they thought Yeltsin's victory was a done deal, as he himself had indicated, why bother voting...
...also is a Roman Catholic who grew up in St. Paul, Minnesota, thus appealing to the swing ethnic voters in the battleground states in the Midwest. And he has elite credentials: law and business degrees from Harvard and a staff job in the Reagan White House. His biggest drawback: someone so young would make Dole seem older than he already is. But the same was said about Dan Quayle...