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Precise drug dosages for individuals are undoubtedly years off, for Kalman's is a counsel of pharmacological perfection. Nonetheless, he and two fellow pharmacologists at Stanford, Drs. Avram Goldstein and Lewis Aronow, have given it considerable impetus with their exhaustive, 884-page study, Principles of Drug Action (Hoeber Medical Division of Harper & Row). The differences among patients in their reactions to drugs may be caused by race, individual heredity, personal idiosyncrasy, or allergic reaction. Enzyme deficiencies and abnormal hemoglobins are found among Negroes and some Mediterranean peoples. In as many as 10% of Negro males, normal doses...
...however, two British psychiatrists who re-examined George's medical records in the light of new medical knowledge are proposing a radically different interpretation. Drs. Ida Macalpine and Richard Hunter, her son, suggest in the British Medical Journal that George III suffered from porphyria, a rare hereditary metabolic disorder that can lead to severe mental disturbances...
...greatest controversy today concerns cancer of the cervix. Again the trouble is insufficient data. What is indisputable is that many, if not most, women on the Pill undergo cellular changes in the cervical region. The question is whether these are precancerous. Two researchers, Drs. Milliard Dubrow and Myron R. Melamed, conducted a three-year study of almost 35,000 women at Manhattan Planned Parenthood clinics. Their report has not been published, and may never be, because technical reviews of the study suggest that it was badly designed. But bits and pieces of the findings have been carefully leaked...
...Drs. Marie A. Capitanio and John A. Kirkpatrick of St. Christopher's Hospital for Children followed deprivation-dwarfism patients over a period of months, carefully comparing X rays of the children's skulls with those of more normal children. They report that the widening sutures are far from being warnings of trouble. While the Philadelphians are still not certain, they believe that the children's widening sutures are being expanded by the youngsters' healthy, growing brains...
...Merck researchers, Drs. Robert G. Denkewalter and Ralph F. Hirschmann, went at it differently. They prepared groups of six to 17 amino acids in linked series. They then put these groups together to form the ultimate 124-link chain. Their product turned out to be the same as the Rockefeller synthetic enzyme; its identity was proved by the way in which it broke down ribonucleic acid...