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Armed with a new biochemical understanding of how myxopyronin functions, along with detailed models of its behavior inside bacterial cells, researchers say drug development is feasible at last. Ebright says the drug could be in clinical human trials within five years. "What has not been possible previously was design of new derivatives ," says Ebright. "It's now possible to make new derivatives that are expressly designed to...have higher potency...
...Rutgers research reflects a much-needed, if slow, renewal of scientific interest in antibiotics development. The last two decades of the 20th century saw nearly zero progress, and in those years several disease-causing bacteria evolved resistance to commonly used drugs. Researchers at the Centers for Disease Control and Prevention found that more than 40% of staph infections in the U.S. in 2006 were MRSA - a bug that now kills more Americans a year than AIDS. Today, the first line of treatment against MRSA is vancomycin, a formidable antibiotic that has been around since the 1950s and is otherwise typically...
What has happened instead, says Zhenkun Ma, head of research at the Global Alliance for TB Drug Development, who was not involved in the new study, is that "we use really old drugs to fight a very new disease. TB evolves every day." So do all other bacteria. Increasingly, the old arsenal of antibiotics is losing power...
Ebright hopes myxopyronin will be especially useful in the battle against drug-resistant tuberculosis, a disease for which clinicians have never had a perfect therapy. The success of TB treatment depends on the destruction of active and dormant bacteria to prevent relapse - something that few existing antibiotics have been able to do. One way to kill a dormant cell is to target biochemical processes that continue even in latency - there aren't many of those. But myxopyronin works by interfering with the enzyme RNA polymerase, which controls gene transcription in cells and is necessary for cell survival, dormant...
...like the junky concept album “T.I. vs T.I.P.” or many of the tracks on “King.” There’s more direction on “Paper Trail,” which turns away from glorifications of the drug game and highlights T.I.’s more profound moments. That isn’t to say that the gloating is gone, too. “56 Bars (Intro),” “Every Chance...