Word: drugged
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...leap from a mouse study to a human study, of course - and an even bigger leap to consider developing a G9a-based treatment for addiction. The protein regulates so many genes that such a drug would almost certainly have unwanted and potentially deadly side effects. But a better understanding of the G9a pathways could lead to the development of safer, more specific drugs. And studying the genes that control G9a itself could also help screen people at risk for cocaine addiction: those with naturally lower levels of the protein would be the ones to watch. Still, there...
...know that the greatest vulnerability [to addiction] occurs when adolescents are exposed," says Dr. Nora Volkow, director of the National Institute on Drug Abuse, which funded the study. "Would you see the same results in adolescent [mice]? And what happens during fetal exposure...
...same time, hints that the drugs could make anyone - not just depressed people - feel better raised tantalizing (and troubling) questions about the future of mood-bending drugs. If Prozac gives you an up even when you're not down, why wouldn't you want to take it? Dr. Peter Kramer of Brown University asked that question in his best-selling 1993 book, Listening to Prozac. A drug that makes patients feel "better than well," he suggested, might give rise to a new era of "cosmetic psychopharmacology," in which reshaping your personality would be as easy as highlighting your hair...
...When it comes to pain and cold medicine, this may be particularly worrisome. Tylenol, NyQuil and other drugs that contain acetaminophen are among the best-selling meds on the market, with more than $2.6 billion in sales in the U.S. in 2008. But acetaminophen can also put stress on the liver. From 1990 to 1998, there were an estimated 56,000 emergency-room visits, 26,000 hospitalizations and 458 deaths related to acetaminophen overdoses, according to the Food and Drug Administration (FDA). These figures include everything from attempted suicides to people who gulped down entire bottles trying to get well...
...already be working overtime - and kids. Unlike doses for adults, those for children tend to be very precise, right down to the milligram, which means even a single, small overdose is something to be avoided. Even more confounding is the counterintuitive way in which the formulation of a drug for infants can differ from that for an older child: the infant's version can actually be stronger since it is often administered in tiny amounts with a medicine dropper. "We've done studies here that show that 50% of the time, parents give the wrong dose" to a child, says...