Word: druggings
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...said that analysis found that mutations at solely sites 46 or 82 lead to weak resistance to Indinavir, an HIV protease inhibitor, but mutations at site 54 alone have no effect. More surprisingly, mutations at sites 54 and 45 actually made the virus even more susceptible to the drug...
Researchers at Harvard and the University of California, San Diego have discovered that mutations in the HIV virus work together to induce drug resistance—a finding that may offer new leads in HIV drug research and therapy...
Resistance arises when mutations in the HIV genome lead to changes in the viral protein structure, thus creating unfavorable conditions for drug binding. As a result of the ease with which the virus mutates, HIV patients eventually develop resistance to all antiviral drugs...
...find the structural mechanism for the HIV virus’s drug resistance, we can see how those mutations will react with the drug molecules and better design drug therapy,” said Jing Zhang, a postdoctoral fellow at Harvard and the lead author of the paper...
...Harvard researchers applied an innovative Bayesian modeling method to gene sequences from both untreated HIV patients and those treated with drugs. Having ran a comprehensive computer search for over a month, the researchers looked for patterns of mutation that were more prevalent among the treated patients—the more common the mutation, the greater the probability of it being responsible for the drug resistance, according to Jun Liu, a professor of statistics at the Harvard School of Public Health and one of the authors of the paper...