Word: duras
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Dates: during 2000-2009
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...decade-plus of putting people into homes everyone knew they could not afford - and then having the whole house of cards fall - is not as much his fault as it is his responsibility, because of the timing of the event. Klein can and should do better. L.E. Dura, Fenton, Mich...
...decade-plus of putting people into homes everyone knew they could not afford--and then having the whole house of cards fall--is not as much his fault as it is his responsibility, because of the timing of the event. Klein can and should do better. L.E. Dura, FENTON, MICH...
...things have occurred in the past couple of decades to alter that view. First, several imaging techniques were developed that allowed doctors to study blood flow in the living brain. Second, scientists learned a great deal more about the nerve endings that are embedded in the dura mater, the fibrous outer covering of the brain. Armed with these tools and that information, researchers concluded that the order of events in a migraine is not as straightforward as they had been taught. The nerve endings in the dura mater appear to act first, releasing proteins that cause the blood vessels...
...block an oncoming migraine was designed to do. Approved in the U.S. in 1993, sumatriptan mimics the action of a neurotransmitter called serotonin, which plays many roles in the brain, including regulation of mood and pain. In the case of migraines, the drug prevents nerve endings in the dura from releasing their stimulatory proteins. No proteins, no pain...
Still, triptans have dramatically changed the lives of millions of migraine sufferers and opened up promising areas of research. Scientists have discovered that triptans, besides affecting serotonin pathways, also directly block one of the stimulatory proteins released by the nerve endings in the dura. New compounds that target this protein, dubbed cgrp, are being tested in Europe. One big problem, says Lars Edvinsson of Lund University in Sweden, "is that the drug can be given only intravenously. We need a cgrp blocker that works as a tablet...