Word: dustin
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...appetites of young men; that women will go to male-oriented movies but men can't be dragged to women's pictures; that an actress's bloom as a box-office icon (Julia Roberts, Jodie Foster) can soon fade, while the appeal of male stars (Sean Connery, Dustin Hoffman) stays solid for decades...
Deep inside Dustin Fagan's brain, a cobwebby growth was spreading. Nothing, it seemed, could arrest the malignant tumor's terrible advance: not surgery, not radiation, not standard chemotherapy. So to save the nine-year-old's life, his doctors decided to kill him--nearly. They increased the dosage of an anticancer agent known as cyclophosphamide to levels that completely wiped out Dustin's bone marrow and thus destroyed his ability to generate new red and white blood cells. Then they revived their small patient by injecting him with healthy marrow that had been drawn in advance from his hipbone...
...Dustin's remarkable recovery--from medulloblastoma, one of the deadliest forms of childhood brain cancer--is more than a tribute to the skill of the cancer specialists, or oncologists, who treated him. It is also one of many small but significant mileposts that mark how far medical science has come in its fight against the cluster of diseases collectively known as cancer. The struggle has been long and hard and, unlike work in other medical fields, has produced few really dramatic breakthroughs. But patient by patient, tumor by tumor, doctors are beginning to gain ground. "We may not know...
Virtually all anticancer drugs interfere with cell division in some fashion. Cyclophosphamide, the compound that finally banished Dustin Fagan's cancer, belongs to a broad class of drugs that damage the DNA molecule by plastering it with sticky cross-links, thus triggering the suicide sequence. By contrast, the taxoids--including taxol, the compound isolated from the bark of the yew tree that was approved by the Food and Drug Administration as a weapon against ovarian cancer in 1992--cause the same suicidal result by deactivating a molecular machine that, just before cell division, separates the DNA in each chromosome into...
...figure: today, when elocution is a nearly lost art and Broadway has faded into the Great White Where?, lots of big-time stars are doing theater. Serious stuff, like Shakespeare and Beckett. Robert De Niro, Dustin Hoffman, Steve Martin, Robin Williams, Keanu Reeves have all paid obeisance to the old muse. Like doing an arty low-budget film, a stab at the classics can be a rite of purification after all those grimy blockbusters...