Word: edelman
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Dates: during 1960-1969
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Last week Dr. Gerald Edelman and his colleagues at Rockefeller University demonstrated that they were equal to the challenge. They announced that they have successfully deciphered the chemical structure of an entire gamma globulin or antibody molecule, one of the basic defenders against disease in all the higher forms of life...
...antibody molecule is a protein, made up of chains of amino acids, of which there are 20 varieties. In 31 years of detailed work, the Edelman team learned by chemical and physical analysis that this particular molecule contains 19,996 atoms (of hydrogen, carbon, nitrogen, oxygen and sulphur) grouped in 1,320 amino-acid units, which in turn are assembled with the aid of chemical bonds into two "light" chains of 214 amino acids apiece and two "heavy" chains of 446 each (see diagram). Schematically, the four chains, in which the acids are strung like beads, look like a letter...
Selective Immunity. Dr. Edelman, 39, a physician and molecular biologist, insists that the chemical description of an antibody molecule is basic science, and he will not speculate on its potential medical uses. But his remarkable accomplishment may well be an important step toward the day when doctors will be able to selectively regulate immune reactions, allowing patients to accept transplants without lowering their resistance to disease...
CHARLES B. EDELMAN Los Angeles
...GOOD GUYS (CBS, 8:30-9 p.m.). Another comedy show. Bob Denver and Herb Edelman star as a glib cabbie and the gullible owner of a diner. Premiere...