Word: effective
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What makes Sendak's book so compelling is its grounding effect: Max has a tantrum and in a flight of fancy visits his wild side, but he is pulled back by a belief in parental love to a supper "still hot," balancing the seesaw of fear and comfort. In expanding the story, Jonze (with co-writer Dave Eggers) invents just enough of Max's home life to convey the forces behind his disobedience. The parents of 9-year-old Max (played by Max Records, whose name and performance suggest he was born for this role) have split...
...colleague, Michael D. Hughes, said he still remembers how Lagakos helped him to “focus on the big picture, doing things that could effect public health and not focus on small details...
...resulting tally, then, would include a much smaller pool of participants, which automatically lessens the significance of whatever effect, if any, the vaccine appeared to have, says Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases. "When you lose statistical power, something that would have been significant in the [original, larger] population, could now fall below significance merely by the lower numbers. That's what happened with this trial," Fauci says...
...does this mean the vaccine was not effective? That depends on whom you ask. Some experts argue that the vaccine's effect, if it exists, is so tiny that it's not worth pursuing in a significant way. They also question whether such a large trial can be considered as a proof of concept. "Doing a 16,000-person trial, it can't be a proof of concept at that point," says Dr. David Ho, director of the Aaron Diamond AIDS Research Center in New York City. "Would I invest in it? The answer is no. There are other things...
Fauci acknowledges that the vaccine's effect is small, but believes that it's an important first step toward understanding how the body fights off HIV. "It's barely significant, yes," he says. "But it's interesting in that it opens up a door for us to be able to pursue more research." Although the number of volunteers who were protected were few, they are still the first who may have been protected at all by an AIDS vaccine and are therefore considered a valuable starting point...