Word: eggan
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...mouse skin cell to reverse its development and return to an embryonic stage at which it produced stem cells. Two other groups, based at Harvard Stem Cell Institute (HSCI) and the Whitehead Institute for Biomedical Research at MIT, obtained similar results working independently. In the final paper, Kevin Eggan, also at HSCI, showed that even fertilized mouse zygotes at the one-cell stage can be reprogrammed to generate stem cells. Previously, biologists had believed that once fertilized embryos embarked on the developmental path, they could not be manipulated to produce stem cells...
...same, and with a few modifications, the scientists hope to have similar success with human cells. "It's likely to be the case that since this discovery is based on such fundamental cell biology principles, that the overarching rules [for mouse and human cells] are the same," says Eggan. "There are subtleties in human embryology that make human development different, but it should work...
...first gene discovered to cause cancer in mice. "Figuring out how to reprogram cells without directly exposing the cell to the cancer-causing effects of these genes is a major area of scientific activity, and would have to occur before we could consider using similar factor in humans," says Eggan...
...This is our first demonstration that it’s not only viable but a very valuable approach. We’re hopeful that we’ll be able to exactly extrapolate this system with human embryonic stem cells,” said Harvard researcher Kevin C. Eggan, the project’s principal investigator. Opponents of human embryonic stem cell research criticize studies such as those envisioned by the Harvard and Columbia teams for leading to the destruction of embryos that could develop into human beings. Last year, President George W. Bush vetoed legislation loosening restrictions on federal...
...emphasized the possibility of “creating cell lines for the study and treatment of disease without the many ethical dilemmas associated with the creation and destruction of embryos.” In a letter addressed to two Congressmen, Assistant Professor of Molecular and Cellular Biology Kevin C. Eggan, Medical School Assistant Professor Chad A. Cowan, and Cabot Professor of the Natural Sciences Douglas A. Melton wrote that they were “surprised” to see their work “used to support arguments that research involving human embryonic stem cells is unnecessary...