Word: elan
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...find a pair of boots with stylish elan at working girl savings, I'd better hit the streets now. By the end of January, footwear options will be limited. Mind you, I don't actually need a pair of boots, but shortly after the New Year's ball in Times Square drops I plan the new year's shopping calendar. Especially in a quasi-economic slowdown, shoppers target seasonal and end-of-season sales. Buying gifts and replacing household and personal items throughout the year can save a lot of money and spare you the holiday crush. And by matching...
Last year one of these highly refined derivatives became the first so-called secretase inhibitor to enter clinical trials with Alzheimer's patients, and others seem sure to follow. In fact, not just Bristol-Myers Squibb but also Amgen, Elan Pharmaceuticals, Eli Lilly, Merck and SmithKline Beecham are racing to develop similar compounds. The reason? Over the past five years, an explosion of insights into the genetics of Alzheimer's has bolstered confidence that gamma secretase and a related enzyme called beta secretase are not innocent bystanders but rather are intimately involved in the disease process...
...knows whether any of these novel compounds will turn into a pharmaceutical Cinderella, but at least the possibility is there. "Compared with what [Alzheimer's researchers] had coming down the pipeline a couple of years ago, it's night and day," says Dale Schenk, vice president of neurobiology at Elan Pharmaceuticals in South San Francisco. "Finally we have moved out of the laboratory and into the clinic...
...third enzyme known as alpha secretase, whose activity, some think, may help protect the brain against Alzheimer's disease. When alpha makes the first cut in the precursor protein, gamma secretase makes a second cut that produces not beta amyloid but an innocuous protein fragment known as p3. Elan and Pharmacia, based in Peapack, N.J., among others, are actively working to develop beta secretase inhibitors...
...plaques were like bits of concrete scattered throughout the brain," says Bristol-Myers' Molinoff. "But there's now intriguing evidence that suggests you can get plaque regression." Some of the most striking evidence comes from studies of a vaccine against beta amyloid that Schenk and his co-workers at Elan have developed. In 1999 they administered their vaccine to mice whose brains were filled with plaques. A short time later, the plaques shrank. Currently the Elan vaccine, like the Bristol-Myers' secretase inhibitor, is in early-phase clinical trials, in which the primary objective is to test for safety...