Word: elan
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...most straightforward approach to fighting Alzheimer's plaques is to target their main ingredient, a protein called beta amyloid. Last summer scientists from Elan Pharmaceuticals, a biotech firm located in Ireland, reported that they had developed a vaccine that could shrink the plaques--at least in mice. Here the idea is to prime the immune system to treat amyloid proteins just as it would any foreign invader and target them for destruction. The concept is somewhat counterintuitive, since most researchers believe that at least part of the damage in Alzheimer's disease is caused by the immune system's overreaction...
Today the Elan School in Poland Spring, Maine, is just that--a school. But in the years from 1978 to 1980, it was something else--an exclusive drug and alcohol clinic for children of the rich and famous. This was where Michael Skakel, 19, a nephew of Ethel Kennedy's and a son of wealth and privilege, spent two years drying out. And according to a book proposal circulated briefly last year by the now 39-year-old Skakel and writer Richard Hoffman, Elan was the scene of a flamboyant--and possibly fateful--therapy. Those who have seen the proposal...
...power to compel testimony on the Moxley case. Although prosecutors cannot comment on the decision, it may have been influenced not only by the Sutton leaks but also by another unusual break. After seeing an episode about the case on TV's Unsolved Mysteries, several alumni of the Elan School called to say that between 1978 and 1980 Skakel admitted involvement in Moxley's killing. Three of them were among the 40 witnesses Thim called. Their testimony presumably buttressed the passage in Skakel's book proposal, which Fuhrman says he passed on to authorities...
...enough 25 years ago, let alone today," has some teeth. Even Fuhrman believes the case will have to move forward "absent forensic evidence." The Sutton report, while intriguing, seems like a better argument for reopening the case than clinching it. And the credibility of Skakel's former "classmates" at Elan is being questioned. Joseph Ricci, who owned the rehab center, has told TIME that the notion of Michael's confession "is just preposterous. I was there, and I would know." The facility had only 100 patients, and if Michael had confessed, "two things would have happened. Everybody in the facility...
...designing a high-rise--in the heart of Manhattan, no less--that is to be the U.S. headquarters for LVMH, the fashion, champagne and other image-heavy-goods conglomerate. Ugly just won't do. But Christian de Portzamparc, the Pritzker-prizewinning French architect, has created a tower with elan. His 23-story building has a kinky, faceted, overlapping-glass facade, like a whimsical piece of origami, which nevertheless abides by all the city's fiddly zoning laws. The mixture of transparent and opalescent glass and the etched patterns on the windows enhance the prismatic effect, and will no doubt make...