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Last year one of these highly refined derivatives became the first so-called secretase inhibitor to enter clinical trials with Alzheimer's patients, and others seem sure to follow. In fact, not just Bristol-Myers Squibb but also Amgen, Elan Pharmaceuticals, Eli Lilly, Merck and SmithKline Beecham are racing to develop similar compounds. The reason? Over the past five years, an explosion of insights into the genetics of Alzheimer's has bolstered confidence that gamma secretase and a related enzyme called beta secretase are not innocent bystanders but rather are intimately involved in the disease process...
...bifurcated Congress. A longtime aide to G.O.P. Senator Richard Lugar, Daniels worked closely with Democrats in the 1970s bailout of Chrysler and New York City. As Ronald Reagan's political director in the 1980s, he salved the egos of Governors and lawmakers. And as senior vice president at Eli Lilly & Co., he transformed the old-line corporate culture amid rapid changes in health-care services, helping fuel a fourfold rise in Lilly's stock. "He builds consensus around the things that aren't peoples' first choice," says Randy Tobias, the firm's chairman emeritus...
Daniels could come under scrutiny if Bush makes good on his campaign promise of a Medicare drug benefit. Eli Lilly has a big stake in making sure it doesn't become an entitlement, which could lead to government price controls. So the issue is a potential conflict of interest for Daniels if he should have stock in the company or plans to return to it. "We'd look for assurances from him that he would not simply represent interests of the pharmaceutical industry," said John Rother of the AARP...
...Veneman, the new Agriculture Secretary designate, all worked for Bush's father. Paul O'Neill, the Treasury designate, spent ten years as a budget whiz in Washington before working for International Paper and Alcoa. Mitch Daniels, the new budget czar, worked for Dick Lugar before going to Eli Lilly...
...Tigers' junior goalie Dave Stathos made 31 saves in the contest, with the only mishap coming on a one-timer from Eli Jeff Hamilton, as Yale began the third period on a power play...