Word: endo
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Dates: during 1980-1989
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...search for a new anticholesterol drug began in Japan. Akiro Endo, a scientist with the pharmaceutical firm Sankyo, wondered whether soil molds that kill cholesterol-containing bacteria might have evolved the ability to block cholesterol synthesis. In 1976, after testing 10,000 compounds, Endo found one that inhibited a key enzyme in the cholesterol-manufacturing process. Researchers at Merck soon discovered similar compounds, including lovastatin, but the finds would have remained research oddities without the Nobel-prizewinning work of UTHSCD's Joseph Goldstein and Michael Brown...
...employees, 60% of them women, work in the final assembly stage, where the tasks are more complicated. Canon's philosophy exhorts workers to avoid the "nine wastes," which include such sins as excess inventory or defects of any kind. The results are nearly picture perfect. Factory Boss Toshio Endo boasts that in a batch of 470,000 lens mounts produced at the plant over the past three months, only two were defective...
...refuse to be seduced. And when they speak out, readers respond by the thousands. Internationally prominent novelists like Kobo Abe (Woman in the Dunes) and Kenzaburo Oe regularly sell 150,000 copies of each book. Other novelists, like Hisashi Inoue, 47, have enjoyed even greater success (see box). Shusako Endo's spare and elegant studies of Christian faith and martyrdom (Silence; The Samurai) have brought the 60-year-old author the title of the Japanese Graham Greene and made him one of the nation's most widely translated writers...