Word: endostain
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Dates: during 1990-1999
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...Endostain, a drug developed b Harrvard researchers in Andrus Professor of Pediatric Surgery M. Judah Folkman's lab at Children's Hospital, recently made national headlines because of its touted effectiveness fighting cancer...
...Endostain, a protein derived from the common body protein collagen, prevents the growth of small capillaries that nourish cell growth .If fights cancer by cutting off the blood supply to tumors, stopping growth of new cancerous cells. The same technique of cutting of the capillary blood supply has now been shown to reduce the accumulation of palques, fatty tissue like cholesteerol which builds up and blocks blood flow in the arteries and leads to heart disease...
...Whether [endostain] can be implemented [ to help humans] based on the animal studies remains to be seen," said Isner, who is chief of vaascular medicine and cardiovascular research at St.Elizabeth's Medical Center in Boston and a professor of medicine and pathology at Tufts University...
...Moulton spaculated atherosclerosis-focused endostain tests on humans may be put on the back burner while the drug tested on cancer patients...
However, according to Moulton, another drug tested in Folkman's lab, TNP_470, has similar effects as endstain on retarding plaque buildup and is being used in human trials. Moluton said she is interested in continuing research on heart disease to investigate the mechasnism behind the success of endostain...
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