Word: endostatin
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...media may be trivializing [Folkman's] contributions by putting all the pressure on one compound, endostatin, to be a silver bullet in the clinic. This is unfair," he says. "[Folkman's] contributions to both angiogenesis inhibitors and stimulators in clinical trials cannot be underestimated...
Ingber adds that to him it seems the media flurry surrounding endostatin trials and Folkman's recent work is attributable at least in part to the perceived novelty of the results...
...contrast to newly discovered, highly publicized proteins like endostatin, Ingber says, TNP-470 has actually already been tested in humans in clinical trials conducted since 1992. In April 1998, the first complete tumor remission in a human using this drug was published as a case report in New England Journal of Medicine, and the drug will likely be entering Phase III trials very soon...
Still, Ingber says, "I think Folkman is truly the pioneer in this field and I guess the media feels that if he believes this [endostatin research] is the most exciting thing around, then they should give it their greatest attention. From this perspective, it is a reasonable response...
Despite the confused coverage of Folkman's work in the media, Ingber says endostatin has the potential to one day be a very important weapon in the fight against cancer and other diseases...