Word: endostatin
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...also reported finding two proteins, angiostatin and endostatin, that stop blood vessel growth in mice--thus starving the cancer--without any observed side effects...
...date, NCI studies using either the mouse orhuman forms of endostatin have not produced themarked regression of these tumors in mice thatFolkman's laboratory has reported," the NCI saidin a press release...
...matter what its configuration, angiostatin could not make a mouse tumor disappear. Not, that is, until Folkman and O'Reilly added to the mix a second molecular fragment, which they called endostatin, from yet another naturally occurring protein. Together, the two compounds destroyed a range of tumors in mice. The results were startling enough that they merited testing in people--which is exactly what Pluda, at the National Cancer Institute, intends to do. How fast those studies can begin depends on how much angiostatin and endostatin EntreMed and its business partner, Bristol-Myers Squibb, can produce and whether they...
...people and their families, talk of safety and efficacy and extended double-blind trials are just so much noise. A treatment that may be available five years from now or next year or even in a few months amounts to no treatment at all. So what if angiostatin and endostatin work only in mice? If there's even a minuscule chance the compounds will cure cancer in humans too, why should the dying have to wait another minute...
Unfortunately, there are plenty of reasons. To start with, the substances are available only in tiny quantities at this point. When scientists first started making endostatin, it took 200 qt. of mouse urine to obtain less than a millionth of an ounce. Turning the compounds out in people-size doses will require entirely different manufacturing techniques. EntreMed claims it now has a way to make lots of endostatin, using yeast cells as tiny factories; angiostatin is proving a lot tougher to mass-produce...