Word: endotoxin
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Working with a lipid emulsion derived by Rogosin researchers from soybeans, Dr. Joseph Parrillo, a leading authority on sepsis at Chicago's Rush medical center, infected 19 pigs with bacteria containing endotoxin, then infused the Rogosin emulsion into eight of them. The results were striking. All 11 of the untreated pigs died, while seven of the treated animals survived. Says Parrillo: "It's kind of convincing...
...disruption to the body's immune response -- caused, for instance, by severe burns, chemotherapy or major abdominal surgery -- allows these rod-shaped bacteria to multiply out of control and invade other parts of the body, eventually entering the bloodstream. Once there, one part of the bacterial cell wall called endotoxin can trigger a cascade of lethal effects, culminating in multiple organ failure and death, sometimes within hours...
...treatment, reported by Dr. Elizabeth Ziegler and colleagues in the New England Journal of Medicine, employs a man-made antibody called HA-1A designed to zero in on the endotoxin molecule and render it harmless. Although the Food and Drug Administration has yet to approve HA-1A for use in the U.S., the agency has given the Pentagon special permission to utilize the antibody in the gulf. Large quantities are on hand in MASH units and field hospitals...
...pair made their initial observations on laboratory animals, injecting some with an endotoxin, a bacterial substance that produces fever, and others with an endotoxin-caffeine combination. Those receiving both developed higher fevers than those injected with the endotoxin alone. The researchers then tried treating the animals with an aspirin-caffeine preparation similar to those sold as patent cold remedies. The combination did not reduce temperature at all. A follow-up study with human volunteers confirmed the animal experiments. When 35 students received typhoid vaccinations, which produce a mild infection and fever, those who were given caffeine had higher temperatures than...
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