Word: endotoxin
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Dates: during 1972-1972
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...pair made their initial observations on laboratory animals, injecting some with an endotoxin, a bacterial substance that produces fever, and others with an endotoxin-caffeine combination. Those receiving both developed higher fevers than those injected with the endotoxin alone. The researchers then tried treating the animals with an aspirin-caffeine preparation similar to those sold as patent cold remedies. The combination did not reduce temperature at all. A follow-up study with human volunteers confirmed the animal experiments. When 35 students received typhoid vaccinations, which produce a mild infection and fever, those who were given caffeine had higher temperatures than...
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