Word: erk
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...goal, says spokeswoman Lisa Erk, "is systemic social change." This means forming a partnership between colleges and their communties to get bars off campus, halt two-for-one drink specials and increase alcohol-free social options. Students, of course, will complain (at Wisconsin the chancellor is sometimes called the "booze cop"). And so might townspeople: why can?t a responsible drinker enjoy a beer or two at the football game, or get a discount for stopping by at happy hour? That's what happens when you craft policy to deal with the worst offenders. The innocents have to sacrifice...
...ERK is well-known for its role in cell growth and division, but this is the first study implicating it in excitotoxic pathways...
...investigators mixed cultured brain cells with an ERK-blocking drug, PD098059, and induced seizures in the cells (seizures are also thought to utilize excess glutamate to promote death in neighboring cells). They found that when the ERK was blocked, the cells were safe from deadly glutamate exposure...
Alessandrini and his colleagues carried out experiments of their own, where they injected the ERK-blocking drug into seven mice and then blocked the blood vessels in their brains...
They found that, on average, the region of cell death in mice receiving the ERK-blocking drug was 55 percent smaller than that of mice not given the drug. Alessandrini noted that in his study, the ERK-blocking drug was administered to the mice before or at the beginning of a stroke, a situation that may not be practical in humans. However, researchers believe that the findings do give hope for discovering other possible ways of stopping a stroke after it has begun...