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Word: estradiol (lookup in dictionary) (lookup stats)
Dates: during 1940-1949
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Usage:

...manly or a woman womanly-or vice versa? Many homosexuals are living proof that physical organs alone are not decisive. Freud and his followers argued that the sexual personality was often determined by seemingly trivial incidents in childhood. When the so-called "sexual hormones" (testosterone in men, estradiol in women) were discovered, many physicians decided that hormones must be the agents which determine sexual behavior. In recent years, tens of thousands of effeminate males and masculine females have been given shots of one or the other...

Author: /time Magazine | Title: Medicine: Hormones & Sex | 9/12/1949 | See Source »

...Kruif's decline might be due to a hormone deficiency. Dr. Bundesen believed that the vitality of men and animals is linked to their sexual vigor. He informed De Kruif that organic chemists had isolated and synthesized the essential product of the male sex glands (the female hormones, estradiol and estrone, had been discovered and put to fruitful use still earlier...

Author: /time Magazine | Title: Medicine: Virility Prolonged | 5/28/1945 | See Source »

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