Word: estrogen
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Conception Odds. Each woman willing to take the experimental treatment was given 25 mg. of diethylstilbestrol (DES), a synthetic estrogen, twice a day for five days. The hormone substitute has long been used to relieve the symptoms of a variety of women's ailments. Five years ago, researchers at Yale University School of Medicine found that it could also prevent pregnancy, apparently by blocking implantation of the fertilized egg in the uterine wall...
...Kuchera's success has been duplicated elsewhere. Several physicians have used DES to prevent pregnancies in rape victims, and Dr. Takey Crist and Cecil Farrington of the University of North Carolina reported last week that they had used an animal estrogen successfully with 94 patients. But neither Dr. Kuchera nor her colleagues see DES as a panacea for unwanted pregnancies. The drug has been linked to cancer of the vagina in the daughters of women who took it for other purposes (TIME, Aug. 2). The Food and Drug Administration has not approved it for general use as a pregnancy...
Beginning in 1946, pregnant women with histories of spontaneous abortions were frequently treated with diethylstilbestrol, an artificial hormone. No one knows the number of miscarriages prevented by stilbestrol among the many thousands of women who took it; by 1960, questions about the estrogen compound's efficacy had induced most doctors to avoid it in treating pregnant women. But there is no doubt that in at least a handful of cases, daughters of women so treated have fallen victim to vaginal cancer. The mothers' use of stilbestrol is suspected of planting a hormonal time bomb that can be deadly...
...boys in Fellini's band. Still, if one cannot have pre-Christian Rome, contemporary London will do. Sunning himself in a graveyard one afternoon, Sloane is taken in-in every sense-by Kath (Beryl Reid). She is a bloated harpy who will never need silicone or estrogen. Enter two gentlemen who provide complications and multiply laughter. Kath's father Dadda (Alan Webb) is a senescent buzzard; her brother Ed (Harry Andrews) is a lantern-jawed caricature of muscle-bound Christianity...
Chlormadinone differs from conventional forms of the Pill in two vital respects: 1) it consists simply of a synthetic analogue of the hormone progesterone and contains none of the estrogen that has been implicated in clotting disorders among Pill users (TIME, Jan. 26); 2) it is taken every day of the year, and not on the 21-days-on, seven-days-off schedule of other forms of the Pill. Like the other versions-and, in fact, like all other potent medications-chlormadinone has its drawbacks. The failure rate, judged by unwanted pregnancies, is slightly higher than with other pills...