Word: estrogen
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...Wilson compares the menopause to diabetes, arguing that both are deficiency diseases. His own efforts to correct woman's menopausal deficiency began in the 1920s. At first he had only crude hormone extracts, which had to be injected. Now there is a plethora of estrogens and of the other sex hormones, progestins and androgens. Most of them are at least partly synthetic, and they can be taken easily by mouth. A couple of years ago, a patient who had kept on taking the birth-control pill Enovid after her menopause gave Dr. Wilson a new insight: the pill-which...
...facts in the current case were simple and clear. Merck Sharp & Dohme was testing a pill containing two synthetic hormones. One is an estrogen, familiar and long in use; the second is a new progestin, closely related to those in pills already available but differing in detailed chemical structure. Although 340 women have taken the still-experimental pill for several months with no apparent ill effects, the manufacturer tried giving exceptionally large doses-20 to 40 times the human dose-to dogs. Two of the dogs in the experiment developed cancer...
...Plank's remarks followed a presentation by Dr. Gregory Pincus, who is known as the "father" of the pill, on the advantages of physiological control of conception. Dr. Plank, however, urged "continued cautious assessment" of the safety of the progestin-estrogen pills...
Both drug companies and academic research institutes have recently spent fortunes trying to isolate a contraceptive on the "nature knows best" reasoning, and they have failed dismally. The truth is that countless plants contain substances that are close chemical kin to the estrogen group of female hormones and, like the estrogens, will indeed prevent conception-but they are neither as good nor as safe as the artificial products now available...
...Drug Administration for marketing by Mead Johnson & Co. rely on the Albright proposal. Called "sequential therapy," the new system uses 21 pills neatly stacked in a tube-16 white on top and five pink at the bottom. Working down the tube, a woman takes the first white pill (an estrogen) five days after beginning menstruation, and carries on with the white pills on a one-a-day schedule until they are finished. Then she takes the pink pills (a progestin) daily for five days. By thus imitating nature, say Mead Johnson and its medical investigators, the new pills provide almost...