Word: estrogen
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...beta-amyloid proteins. They are also re-examining existing drugs that may offer therapeutic pportunities. Some experts, for example, speculate that antioxidants such as vitamin E and anti-inflammatories such as ibuprofen could help shield neurons from chemical damage. Others have seized on tantalizing hints that the female hormone estrogen may delay the onset of Alzheimer's disease in postmenopausal women. Estrogen appears to foster the brain's health by, among other things, spurring the growth of connections that link a single neuron to many others...
...test positive may reduce that risk considerably, says Mark Skolnick, who led the team at Salt Lake City's Myriad Genetics that isolated the gene. He suggests they adopt a program that includes, among other things, exercise and a low-fat diet, and that they avoid doses of estrogen after menopause. Some go further, opting to have their ovaries removed or even choosing prophylactic mastectomies...
...real battle, then, is to prevent such fractures in the first place, and that involves slowing the onset of osteoporosis, a disease that makes bones brittle. Among menopausal women, estrogen-replacement therapy has gained wide usage, despite its risks of depression and endometrial cancer. A newer treatment that received federal approval just last year involves the use of amino-bisphosphonates, a class of drugs that inhibit the cells that govern bone loss...
...high doses of vitamins can reduce the effects of oxygen radicals. The nia is supporting limited research into the risks and benefits of boosting the levels of three hormones that decrease as people age: melatonin, which affects sleep cycles; dehydroepiandrosterone, a product of the adrenal glands that converts to estrogen and testosterone; and human-growth hormone, which affects bone and organ development, as well as metabolic rate. Limited lab tests on animals suggest to some investigators that melatonin may serve as an antioxidant, wiping out the free radicals that can harm the body's cells. But scientists are cautious because...
...change," marking the end of a woman's childbearing years, results in her body's virtually shutting down production of the hormone estrogen, with attendant hot flashes, irritability and weight gain. Post-menopausal women are also at higher risk for heart disease and osteoporosis (among other things, estrogen prevents the buildup of plaque in blood vessels and protects bone from thinning). On the plus side, the drop in estrogen reduces a woman's risk of developing breast cancer. Estrogen-replacement therapy--whether by pill, skin patch, above, or injection--provides just enough estrogen to prevent the unpleasant symptoms of menopause...