Word: estrogen
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...villain, according to Sáenz and other Puerto Rican doctors, could be the local food-beef, chicken and that fundamental childhood staple, milk. These physicians suspect that meat and milk producers are unlawfully using estrogen and related compounds, including the federally banned carcinogen diethylstilbestrol (DES), to add heft to their animals. High consumption of such chemicals has been known to cause premature thelarche, and, say the doctors, when patients are withdrawn from the suspect foods, nearly all recover within six to eight months. The charges have triggered a spate of Government investigations, a volley of denials by the meat...
...attempts to assess the merit of the doctors' charges have been inconclusive. An FDA investigation in August found that two out of 17 poultry samples from Puerto Rico were "suspect for estrogenic activity." Despite this, says FDA District Director Lynn Campbell, the analysis "has uncovered no evidence of the unlawful use or abuse of estrogen or hormone-like compounds...
Until recently, treatment has generally been limited to prescribing supplemental estrogen, to slow the resorption rate, and calcium, to facilitate the formation of new bone.* Using a computerized axial tomography scanner, doctors at the University of California in San Francisco are able to take three-dimensional X rays of the bones, measure the loss of minerals and devise an estrogen dosage sufficient to maintain the resorption balance. Says Kaiser-Permanente Endocrinologist Dr. Bruce Ettinger, who does research at U.C.S.F.: "We've been trying to find the smallest dose of estrogen that will prevent osteoporosis. I think we have...
Keeping the dosage to a minimum is crucial because estrogen has been found to increase the incidence of uterine cancer. Doctors acknowledge the risk, but many say it is worth taking. Explains Endocrinologist Dr. Michael Kleerekoper of Detroit's Henry Ford Hospital: "The cancer produced by estrogen is curable. Osteoporosis is not. It's a trade-off." Adds Dr. Gilbert S. Gordan, professor of medicine at U.C.S.F. "What we are talking about is saving women a lot of pain and deformity and fracture...
Doctors at Henry Ford Hospital and the Mayo Clinic in Rochester, Minn., believe they may have found a treatment that is as effective as estrogen but without its troubling side effects. In a twelve-year study, Dr. B. Lawrence Riggs and a team of Mayo physicians treated women with large doses of sodium fluoride combined with calcium. Sodium fluoride stimulates bone-forming cells to produce new bone faster than the old bone is resorbed. The Mayo researchers will now study the mechanical quality of the new bone, trying to determine if it is as strong as the tissue produced normally...