Word: estrogenic
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Dates: during 1960-1969
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...THROMBOPHLEBITIS. Women on 20-day pills that combine a progestin (a synthetic that acts like a pregnancy hormone) with a minute quantity of estrogen react as though they were "a little bit pregnant." Changes in the blood resemble those of pregnancy-including, for some women, an increased tendency for blood clots to form in inflamed leg veins. From there, they may travel to the lungs. A committee on drug safety studied every suspected case it could find in Britain and concluded that a woman taking such pills "incurs a slightly increased risk of developing thromboembolic disorders, but that risk...
Other hormone investigators took a different direction, concentrating on the rediscovered, though still not fully understood, powers of estrogen. From the fifth to the 20th day of a normal woman's cycle, her estrogen level is fairly steady, except for a dip at the time of ovulation. If they could prevent this dip, the researchers reasoned, they could prevent ovulation. They felt it would be more natural to do this by providing nothing but added estrogen until the 20th day, and then giving progestin only briefly. San Antonio Researcher Dr. Joseph W. Goldzieher worked with Syntex Laboratories to develop...
...progestin (with a protective smidgen of estrogen added) for five or six days. The sequentials, like the combinations, tend to regularize the cycle, and most women who take them have an acceptably mild menstrual period...
...medication ever devised for any purpose. When a woman "on the pills" has become pregnant, it has been shown in virtually every case-and suspected in the others-that she has skipped a pill or two. The failure rate is slightly higher on the sequentials, apparently because the estrogen taken early in the cycle wears off rapidly, and a single day's missed pill may spell pregnancy. The progestin combinations afford a slightly broader margin of safety...
Prescribed for Acne. Some women complain that the pills cause acne. This is physiologically impossible, because acne is associated with an excess of androgens (male hormone) over estrogen. Since the pills supply estrogen, they are often prescribed for treatment of acne. Other women complain that they don't menstruate while on the pills. This is seldom true, because of the pills' regularizing effect. A Los Angeles mother says that the pill was "magic-a godsend" for her 15-year-old daughter, whose menstruation was so irregular and heavy that she suffered serious blood loss and near-shock...