Word: estrogenic
(lookup in dictionary)
(lookup stats)
Dates: during 1960-1969
Sort By: most recent first
(reverse)
...team working at each center. But Physiologist Gregory Pincus of the Worcester Foundation for Experimental Biology and Gynecologist John Rock of Harvard University rate high among the pioneers of oral contraception. It was at Harvard, too, that Dr. Fuller Albright noted in the mid-1940s that an excess of estrogen* in the bloodstream soon after the end of menstruation somehow prevented ovulation. A few years later, Pincus and Rock were working together to find a way of helping subfertile women ovulate, and thus conceive. They first had to regularize the woman's cycle, and they hit upon a synthetic...
...taking it, she had what seemed like a normal but mild menstrual period. There were few side effects. But as the drug was further purified, Dr. Rock began to hear patients complain of too much "breakthrough bleeding" in mid-cycle. Analysis showed that the purified drug contained no detectable estrogen. Apparently estrogen, even in the most minute quantity, prevented some side effects, including unwanted bleeding. So when Chicago's G. D. Searle & Co., which had worked closely with Pincus and Rock, began making "the Pincus pills" as Enovid in 1957, the formulation contained 66 parts progestin to one part...
...Wilson compares the menopause to diabetes, arguing that both are deficiency diseases. His own efforts to correct woman's menopausal deficiency began in the 1920s. At first he had only crude hormone extracts, which had to be injected. Now there is a plethora of estrogens and of the other sex hormones, progestins and androgens. Most of them are at least partly synthetic, and they can be taken easily by mouth. A couple of years ago, a patient who had kept on taking the birth-control pill Enovid after her menopause gave Dr. Wilson a new insight: the pill-which...
...woman just beginning to notice the hot flushes and sweats that are the warning signs of oncoming menopause, Dr. Wilson prescribes estrogen tablets daily for seven to 21 days a month, adjusting the dosage until her femininity index is restored to 80% or better. For a woman with more severe symptoms, he prescribes estrogens plus a ten-day course of a synthetic progesterone substitute. A woman who is clearly past the menopause gets estrogen daily for six weeks plus a progestin tablet on each of the last ten days. The effect of this treatment is to restore a pseudomenstrual cycle...
...facts in the current case were simple and clear. Merck Sharp & Dohme was testing a pill containing two synthetic hormones. One is an estrogen, familiar and long in use; the second is a new progestin, closely related to those in pills already available but differing in detailed chemical structure. Although 340 women have taken the still-experimental pill for several months with no apparent ill effects, the manufacturer tried giving exceptionally large doses-20 to 40 times the human dose-to dogs. Two of the dogs in the experiment developed cancer...