Word: estrogenic
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Dates: during 1980-1989
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...Women who smoke or exercise regularly reduce their estrogen levels which can influence whether or not they get the disease," Cramer said. "They may lighten their periods which stops the tissue from growing...
...findings fit in with previous studies on estrogen levels. Women who smoke have slightly lower estrogen levels, and endometriosis is estrogen dependent," said Robert Balbieri, a clinical fellow in obstetrics and gynecology who also studies the disease...
...varies from patient to patient. As a result, repeated monitoring of Pergonal's effect is essential. Says Dr. Roger Lobo, chief of the division of infertility at U.S.C.: "We do not give Pergonal unless we are able to monitor." One monitoring procedure consists of measuring levels of the hormone estrogen in a patient's blood or urine. As the follicles mature, hormone levels gradually increase. The higher the estrogen level, the likelier it becomes that more than one egg has matured. Another procedure is the sonar-scanning technique called ultrasound, which produces black-and-white images of a woman...
Tamoxifen's effectiveness stems from the fact that the proliferation of breast-cancer cells in two-thirds of older women seems dependent on estrogen, the female sex hormone. The drug acts by blocking receptors for estrogen on the surfaces of cells that have migrated from the breast tumor, thus halting the division of the cells and preventing them from seeding tumors in other parts of the body. Unlike conventional chemotherapy, which usually causes loss of hair and severe nausea, tamoxifen produces only minor side effects, such as hot flashes and mild nausea, and only in about one-quarter of patients...
Still, the drug is not a cure-all. The NIH panel reported that it is ineffective against breast-cancer cells that are not estrogen dependent and seems to have little effect in premenopausal women, who respond best to a combination of chemotherapy drugs. The panel stressed that most older breast- cancer victims whose lymph nodes have not been invaded by malignant cells need neither tamoxifen nor chemotherapy after surgery, but urged that they have frequent checkups...