Word: estrogenic
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Dates: during 2000-2009
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...Initiative (WHI) are adding yet another chapter to the continuing (and confusing) story of hormone therapy (HT) taken during and after menopause. In the latest report, appearing in the Journal of the American Medical Association (JAMA), the study doctors report that the health risks of taking the combined hormones estrogen and progestin can linger for up to three years after women stop taking them...
...right? Opponents of bisphenol A say official safety figures are far too high, given what the chemical, which mimics the hormone estrogen in the body, does in animals. In the lab, even low exposure levels - adjusted for body weight - have been linked to a variety of sex-hormone-imbalance effects, including breast and prostate cancer, early puberty, miscarriage, low sperm count, and immune-system changes. Critics also claim that in developing infants, such sex-hormone effects may come into play at exposure levels far below what health authorities have deemed safe for adults. "The reproductive system is developing, the brain...
...therapy. "I was surprised by the results," says Berry. "I was expecting some subsets of women to show some survival benefit. Many studies had been suggesting that there were some patients, such as young patients and women with triple negative cancer" - that is, cancer cells that lack receptors for estrogen, progesterone or HER2, which makes them difficult to treat with drugs - "that would benefit. But our analysis shows that's not true...
...Your story focused mainly on the treatment of breast cancer and said little about prevention. Recent scientific studies suggest that pesticides - particularly the notorious endosulfan, which mimics estrogen in its effects on the body - have helped boost breast cancer rates worldwide. Countries that make liberal use of pesticides are now paying the price in rising rates of breast cancer. We need insight into the causes of this insidious disease so we can pressure farmers and governments to mend their ways. Bill Murray, Wellington...
...Chemotherapy decisions are similarly dictated by pocketbook considerations. The greater likelihood of ER-negative breast cancer in Africans and Asians means that such drugs as the estrogen blockers are not on the menu of pharmaceutical options. That rules out one of the cheapest and most available breast-cancer drugs in Africa: a $150-a-dose generic version of tamoxifen (and even that would be far too expensive for many women). Traditional chemotherapy may cost $20,000 or more. Merely determining which type of cancer a woman has may require genetic testing, which can add an additional...