Word: estrogenic
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...women linked adult weight gain to a higher lifetime risk for all types, stages and grades of breast cancer, particularly advanced malignancies. The risk for women who gained more than 60 lbs. was three times as great. Reason: breast-cancer risk is linked to lifetime levels of the hormone estrogen. Fat tissue increases circulating estrogen, thereby adding to the risk...
...report that interested me most looked at the association between breast cancer and soy-based foods. This is a controversial topic because soy contains isoflavones, some of which in isolated form can stimulate the growth of estrogen-receptor-positive breast-cancer cells. That's why many Western doctors warn women against eating soy. Yet the epidemiological evidence has been promising: Asian women on diets rich in soy have significantly lower rates of breast cancer than Western women have...
...news came in another large population study, this one of more than 90,000 nurses. A report published in the Archives of Internal Medicine found that the risk of estrogen- and progesterone-receptor-positive breast cancer increased most in those nurses who ate the most red meat. Women who ate more than 1 1/2 servings of red meat a day had nearly double the risk, compared with those who ate three or fewer servings a week. The authors offered several theories for what's behind the correlation. One possibility is that red meat delivers too much iron in a form...
...recent study headed by researchers at the Harvard-affiliated Dana-Farber Cancer Institute has identified a complete map of the genetic regions that may influence how estrogen contributes to breast cancer—results that could advance clinical treatment for breast cancer patients. The study identifies the molecular “control panels,” which consists of thousands of on-off switches for genes, that may be part of the mechanism by which estrogen regulates breast cancer. The findings—to be published in Nature Genetics this month—may help individualize treatment for breast cancer...
...paper published in February in the International Journal of Epidemiology, Campos and others reviewed what medicine knows about how fat-or adiposity-is supposed to cause disease. They concluded that with the exception of osteoarthritis, where increased weight contributes to wear on joints, and a few cancers where estrogen originating in fat tissue may play a role, "causal links between body fat and disease remain hypothetical." They cite a recent U.S. study that found women who'd had an average of 10 kg of fat removed by liposuction had no improvements in health markers over the next three months...