Word: estrogenic
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...Initiative (WHI) are adding yet another chapter to the continuing (and confusing) story of hormone therapy (HT) taken during and after menopause. In the latest report, appearing in the Journal of the American Medical Association (JAMA), the study doctors report that the health risks of taking the combined hormones estrogen and progestin can linger for up to three years after women stop taking them...
...good news is that many of the other health risks associated with hormone therapy -heart disease and blood clotting, for example - did diminish rapidly once the hormones were stopped. Less welcome is the fact that any benefits derived from estrogen and progestin in keeping bones strong also dissipated soon after the women terminated their hormone therapy...
...While the fact that HT's risks may last longer than any woman would like, doctors stress that this risk is still very small. The overall risk of cancer, for instance, among women taking estrogen and progestin, comes to three extra cases per 1000 women per year. For breast cancer, the study found one extra case per 1000 women per year. "It's helpful to translate the findings into absolute cases," notes Dr. JoAnn Manson, chief of preventive medicine at Harvard's Brigham and Women's Hospital. "So for women who are having distressing menopausal symptoms, who are not sleeping...
...right? Opponents of bisphenol A say official safety figures are far too high, given what the chemical, which mimics the hormone estrogen in the body, does in animals. In the lab, even low exposure levels - adjusted for body weight - have been linked to a variety of sex-hormone-imbalance effects, including breast and prostate cancer, early puberty, miscarriage, low sperm count, and immune-system changes. Critics also claim that in developing infants, such sex-hormone effects may come into play at exposure levels far below what health authorities have deemed safe for adults. "The reproductive system is developing, the brain...
...therapy. "I was surprised by the results," says Berry. "I was expecting some subsets of women to show some survival benefit. Many studies had been suggesting that there were some patients, such as young patients and women with triple negative cancer" - that is, cancer cells that lack receptors for estrogen, progesterone or HER2, which makes them difficult to treat with drugs - "that would benefit. But our analysis shows that's not true...