Word: estrogenous
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Dates: during 2000-2009
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...Initiative (WHI), the largest and longest-running survey of the effects of hormone therapy in post-menopausal women. It was the WHI, back in 2002, that turned everything that doctors and patients had believed about the benefits of hormone therapy on its head. The federally funded trial revealed that estrogen and progestin after menopause did not protect women against heart disease, as doctors had previously thought, but in fact increased their risk of heart attack, stroke and breast cancer. After years of recommending the therapy for women well past menopause, doctors then pulled back, prescribing it only for women having...
...just experiencing menopause. And they found that younger post-menopausal women actually enjoyed a lower risk of adverse health effects from hormone therapy than their older counterparts. The new NEJM study specifically reports that women between the ages of 50 and 59 who have had hysterectomies and therefore used estrogen alone (not the estrogen-progestin combination) showed less calcium-based plaque - up to 40% less - in their heart arteries than those on placebo. That's great news for the millions of women struggling with the disruptive symptoms of menopause, but who have been too afraid of the health risks...
Aging is never easy, particularly during menopause. But for 30 years women could at least depend on estrogen and progestin supplements, a comforting hormonal hand to hold that would not only ease the uncomfortable symptoms of getting older but also keep skin supple and hair lustrous. Doctors even encouraged women well into their 70s to take the treatments, on the basis of studies showing that they protected against heart disease and cushioned bones against osteoporosis-related fractures...
...same, unfortunately, doesn't hold true for older women. Estrogen and progestin have a habit of aggravating the hard, artery-clogging plaques that develop naturally with age. On the basis of animal studies and other heart-disease trials in human patients, the authors suspect that hormone therapy encourages the clots that form around these plaques to rupture and cause heart attacks. Nonetheless, the latest study offers a backward sort of good news, suggesting that intense menopausal symptoms may be a kind of early warning system, since women who suffer the most also tend to harbor more risk factors for heart...
Jessica S. Benjamin ’07 pointed out that estrogen and progestin medications are commonly used for treatments other than birth control...