Word: estrogenous
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Dates: during 2000-2009
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...woman's chances of surviving breast cancer, perhaps one of the most powerful is the simple matter of race. Most women in the U.S. are of European ancestry, and the majority of those who develop breast cancer are struck by a type that is partly stimulated by exposure to estrogen. This is one reason the disease usually hits in middle age, after 25 or so years of the monthly hormonal surges associated with ovulation and menstruation. Since the cancer relies on estrogen to grow, drugs like tamoxifen and Herceptin, which block hormone receptors on malignant cells, can help starve...
...Asian women, as well as black women in the U.S. and Africa, are at higher risk of developing a more aggressive form of breast cancer known as estrogen-receptor negative, or ER-negative. That illness strikes an average of 10 years earlier than the other variety and is indifferent to drugs that block estrogen since it isn't fed by estrogen in the first place. Worse, research findings released in June 2006 showed that 40% of premenopausal African-American breast-cancer patients have an even more dangerous form of ER-negative cancer called the basal-like subtype, resistant not only...
...number of children they are having. Research shows that women who give birth to fewer than two children have a higher risk of developing breast cancer than women who have larger broods. Part of the reason is probably that pregnancy and nursing provide the body with a sort of estrogen holiday, as the menstrual cycle is shut down for at least nine months and often a lot longer...
...April, another WHI study published in the New England Journal of Medicine found that estrogen-alone therapy benefited women between ages 50 and 59 who had had hysterectomies; these women had up to 40% less calcified plaque build-up in their arteries compared with women on a placebo. In the coming years, other trials, such as the Early Versus Late Intervention Trial With Estradiol (ELITE) and the Kronos Early Estrogen Prevention Study (KEEPS), will provide more data on estrogen's effect on women's health, particularly cardiovascular health, says Rocca...
...however, his new studies may well change standards of care. Women who are considering a hysterectomy or ovary removal now also need to be aware of the increased risk of dementia, says Shuster, who encourages patients who have had a hysterectomy and oophorectomy at a young age to take estrogen until the natural age of menopause, if not beyond. "The big news is that we shouldn't be withdrawing estrogen from women who need it," says Shuster. "Medically, legally, there is an exaggerated fear of prescribing estrogen, and women have a fear of taking estrogen because...