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After centuries of speculation, most of it idle and all of it profitless, typical gout was recognized in 1931 as an "inborn error of metabolism," indicating that something was wrong with the patients' enzyme systems. But what? Although it was easy to show that victims had an excess of uric acid in their blood, the metabolic pathways by which it got there remained hidden in the biochemical jungle. Then in Baltimore, Pediatrician William L. Nyhan Jr. and Dr. Michael Lesch saw two retarded brothers with the palsy and biting symptoms. It has since been learned that a substance...

Author: /time Magazine | Title: Metabolism: Gout & the Missing Enzyme | 2/2/1968 | See Source »

Kasperak rallied through most of the week. But then he suffered a serious setback. Because of his poor liver function, an excess of bilirubin (a by-product of hemoglobin, the oxygen-carrying protein in blood) began to build up in his system, and doctors scheduled another massive transfusion to remove impurities from his blood. Through it all, the one organ that consistently worked best was his acquired heart...

Author: /time Magazine | Title: Medicine: Michael Kasperak | 1/19/1968 | See Source »

What met his eye last week was not a paucity of happenings but 1967's "ten grossest excesses." It was a brilliant, unpartisan, vindictive selection. Charles de Gaulle was there, of course, along with Mao and his Great Proletarian Cultural Revolution. The 1967 football season, hanging on "like a summer cold," qualified. So did Jacqueline Kennedy magazine covers and the movie Casino Royale, "the utter boring vacuity of the put-on carried to excess." Among gross literary excesses there was, happily, Marshall McLuhan's "losing battle with the English language," and The Story of O, "unarguably the dullest...

Author: /time Magazine | Title: Columnists: The Quiet Subversive | 1/19/1968 | See Source »

...phrases clearly imply," Seltzer said, "that the consequence of smoking cigarettes is a variable amount of excess premature coronary heart disease deaths. But no such implications can be drawn from the conclusions of the Surgeon General's Committee...

Author: NO WRITER ATTRIBUTED | Title: Harvard Scientist Counters Claim That Smoking Is a Heart Threat | 1/16/1968 | See Source »

...there was any trait the old London Times carried to excess, it was diffidence. The paper never talked about itself and did not even give its correspondents bylines. Last week the new Times showed once again how much it has changed by running a four-page spread in the Sunday Times magazine boasting of its achievements in the year since it was bought by Lord Thomson of Fleet. Complete with drawings of Thomson, his editor and the paper's heroes, the article told how the "most dignified newspaper in the world hustled its way to being the most talked...

Author: /time Magazine | Title: Newspapers: The Great Haunch Forward | 1/5/1968 | See Source »

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