Word: expressionism
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The new sports car, wrapped around a 260-h.p. engine and to be priced at a mere $30,000 when it hits showrooms next year, is an expression of what Nakamura thinks the brand ought to be: affordable, with a little more risk and a lot more pizazz. Says Nakamura...
The overall patterns of gene expression in cells interest drug designers because they provide a molecular lineup of potential drug targets. But scientists trying to identify those targets have long been limited to probing active genes one at a time. No longer. Microarray kits, like those made by Affymetrix, based...
To probe cellular gene activity en masse, scientists first isolate the molecules that translate genes into proteins. They then copy these molecules into their corresponding DNA sequences, tag those sequences with fluorescent markers and pour the tagged sequences over the microarray. Active genes in this biochemical stew stick like Velcro...
It has also created something of a microarray gold rush. Several firms--from pioneering Affymetrix to the upstart Incyte Genomics, based in Palo Alto, Calif.--help pharmaceutical companies identify drug targets found exclusively in diseased cells. Others, like Phase-1 Molecular Toxicology of Santa Fe, N.M., sell chips that test...
For example, one amateur proposed to study the facial expression of gophers under extreme pain by developing a device that would chop the animals' heads off the moment they emerged from their holes and drop them directly into a vat of liquid nitrogen so that their expressions would be preserved...