Word: fap
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Dates: during 1980-1989
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...classic instance of personnel shaping policy was President Richard ^ Nixon's embrace, in his first term, of the Family Assistance Plan, a form of guaranteed income for poor families. FAP was largely a Democratic proposal. The first draft was submitted by two Democratic holdovers in the upper bureaucracy who were so skeptical of getting a hearing that they referred to it as the Christian Working Man's Anti-Communist National Defense Rivers and Harbors Act of 1969. But their handiwork caught the eye of another Democrat, Daniel Patrick Moynihan, who had come into the Nixon White House as a presidential...
Bodmer's team studied 13 families with familial adenomatous polyposis (FAP), a rare hereditary condition affecting adolescents in which the large intestine is carpeted with hundreds of small growths called polyps, which frequently become cancerous. After reading about a boy who suffered from several disorders, including FAP, that seemed linked to a missing portion of chromosome No. 5,* the researchers hypothesized that all FAP victims lack the same genetic material. They were right. Afflicted patients had the chromosome defects; healthy ones did not. The scientists further postulated that a person with FAP inherits from one parent a healthy gene that...
...FAP accounts for less than 1% of the 170,000 new cases of colorectal cancerdiagnosed in the U.S. and Britain each year. That led Bodmer to ask, "Could the same gene be involved in the normal run of colon cancers?" The researchers analyzed tumors removed from 45 patients with common colorectal cancer. Result: the section of chromosome 5 that contains the FAP gene was missing in more than 25% of the cases. The finding suggested that such cancers occur only after one protective gene is lost and the other is inactivated. Says Gastroenterologist Sidney Winawer, of the Memorial Sloan-Kettering...