Word: farber
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Dates: during 1950-1959
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...ingenious than simply poisoning the cancer cell was the idea that it might be fooled into accepting, instead of a normal food substance (metabolite), an analogue (close chemical kin) to fill the metabolite's place but yield no nourishment. First to use antimetabolites this way was Dr. Sidney Farber of Boston Children's Hospital and the Children's Cancer Research Foundation. Knowing that leukemic cells are avid for the vitamin folic acid, he began in 1947 to treat child victims of acute leukemia with analogues of folic acid. Lederle Laboratories sent Dr. Farber two, aminopterin and amethopterin...
...mercaptopurine, which interferes with cell nutrition by supplying a counterfeit purine. Physicians treating acute leukemia now ring the changes on these, using one until it loses its effect, then switching to another, sometimes back to the first. No child victims of acute leukemia have yet been saved, but Dr. Farber can report a heartening gain. A dozen years ago, young leukemia patients lived an average of only three or four months, mostly in misery, after their disease was diagnosed. Now the average is at least a year; some live two or three years, and a few still longer. During their...
...ARTHUR FARBER Hartford, Conn...
...Farber, chairman of the Cancer Chemotherapy National Committee, said that 100,000 industrial compounds remain to be tested in the search for a cancer cure...
Stepup in the government's cancer research program, Farber stated, is a result of President Eisenhower's recent request to Congress for increased appropriations in the field. The largest sum requested by Eisenhower was intended for cancer research...