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...same principles are now leading to novel treatments for reviving dying heart tissue, restoring circulation to tissues crippled by diabetes and improving vision in patients with macular degeneration. His theories may yet impact the treatment of other conditions, including obesity: "More recently, he had the idea that fat cells relied on blood vessels just like tumors, so you could control obesity by using blood vessel-growth inhibitors," says Li, who was inspired by Folkman to co-found an organization that promotes research in the field...

Author: /time Magazine | Title: Judah Folkman, Cancer Pioneer | 1/16/2008 | See Source »

...expect a private equity firm to find the excess fat in a company; and one that operates in the decadent music business ought to be easier than most. But ensuring that company has a long-term future is trickier. On that score, Hands has a decent back catalogue. First with Japanese bank Nomura, and more recently at Terra Firma, the 48-year-old boosted the fortunes of a slew of companies, from a waste-recycling group to a chain of pubs...

Author: /time Magazine | Title: Big Cuts Planned at EMI | 1/15/2008 | See Source »

Want to know how many cheeseburgers you'd have to eat before they start doing damage to your body? The answer, according to a review of new dietary research, is just one. Just one high-fat, high-sugar meal can trigger a biochemical cascade, causing inflammation of blood vessels and immediate, detrimental changes to the nervous system, according to the paper, published this week in the Journal of the American College of Cardiology. And just one healthy meal helps return your body to its optimal state. "Your health and vigor, at a very basic level, are as good as your...

Author: /time Magazine | Title: One Meal to Good (or Bad) Health | 1/15/2008 | See Source »

...lower the risk of heart disease by doing more than just lowering cholesterol - studies have shown that statins can also lower inflammatory factors that can aggravate plaques, causing them to burst and block heart arteries, as well as reduce amounts of triglycerides, a particularly dangerous form of fat for the heart. "The bottom line is that we just don't know what Vytorin does, because we don't have the clinical trials," he says. "We know Vytorin blocks absorption of cholesterol. But what else does it block - something else in the diet that could be beneficial? We just...

Author: /time Magazine | Title: Is Vytorin a Failure? | 1/15/2008 | See Source »

...actually the combination of two drugs - one of the early statin medications, simvastatin (also known as Zocor), made by Merck, and ezetimibe, or Zetia, made by Schering-Plough. Ezetimibe is the first cholesterol-lowering medication that works by blocking absorption of cholesterol in the gut, rather than regulating the fat's production in the liver, like other statins do. ENHANCE compared the effect of Vytorin to simvastatin alone, and showed little difference between the two medications when it came to plaque size in the arteries. Simvastatin came off patent in 2006, and these results suggest that the generic form...

Author: /time Magazine | Title: Is Vytorin a Failure? | 1/15/2008 | See Source »

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