Word: fatted
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...earned $219.2 million on a $29 million budget. It's now the all-time top grosser in the based-on-a-true-story genre (unless you count The Passion of the Christ). At the moment it trails only E.T., the first Narnia saga, New Moon, Twister and My Big Fat Greek Wedding among movies with a woman as the top-billed performer - and Bullock is the only lead actress in those films with real star power. So by any standard, The Blind Side...
...heretical idea. After all, we have had a long-standing deal with biology: whatever choices we make during our lives might ruin our short-term memory or make us fat or hasten death, but they won't change our genes - our actual DNA. Which meant that when we had kids of our own, the genetic slate would be wiped clean...
...linked with other types of unhealthy "self-medication": for instance, cigarette smoking (which accounts for the increased rate of emphysema among high ACE scorers) and drug abuse (having four or more ACEs increases the risk of injectable-drug use by a factor of 10). As Felitti puts it, "Being fat [or having other unhealthy behaviors] is not the problem. It's the solution...
...most of human evolution, a stressful world would have been marked by famines or periods of starvation, and that environment might have resulted in a particular pattern of gene expression that would have prompted the body to store more fat in preparation for the next bout of scarcity. Today, of course, the same response to stress would result in obesity. This theory of a thrifty fat-storing system that kicks in under high levels of early stress was originally proposed by British physician David Barker. (See pictures from an X-ray studio...
...particularly - is constantly stressful, it would be incredibly energy-consuming, says Dr. Bruce Perry, senior fellow at the ChildTrauma Academy. "If your genes get the message that you are entering a stressful world, it makes complete adaptive sense to take the existing metabolism and tune it up to deposit fat and store energy to prepare for what the body is expecting will be a challenging and stressful life," he says...