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...bold strategy and one that has never been tried before in the AIDS field, but Ho is willing to stake his reputation and that of his nearly 20-year-old facility, the Aaron Diamond AIDS Research Center (ADARC) in New York City, on his hunch. So is the Bill & Melinda Gates Foundation, which has steered nearly $7 million his way to pursue the theory. Ho has redirected more than half of his lab to the project, and the results so far have reignited his passion for discovery; he's now back at the lab bench overseeing experiments...
...help breaking into a grin whenever he discusses the new project, and smiles haven't come easily to him of late. In the 1990s, he and ADARC established themselves as leaders in the AIDS field by pioneering the early use of the antiretroviral (ARV) cocktails that have reduced the death rate from AIDS (for which Ho was named TIME's Person of the Year in 1996). But in recent years, the center has suffered a series of setbacks, including a scientific paper that required a partial retraction, and the departure of key scientists. These challenges have some in the field...
First Responder Whatever successes Ho does or doesn't have ahead of him, he long ago earned his credentials in the AIDS field. As a physician at the University of California, Los Angeles, in the early 1980s, he began keeping a diary of patients who were rushed to the emergency room with a mysterious amalgam of symptoms such as pneumonia, cancer and, most important, a devastating drop in immune function. After a few months, he noticed a pattern: most of the patients were gay men. Intrigued, he became nearly obsessive about chronicling the growing wave of cases. Within two years...
...preoccupation with HIV only grew as the virus continued to baffle scientists. Expecting the unexpected was the best way to confront HIV, he soon learned, and he quickly amassed an impressive array of scientific firsts in the field. As director of ADARC, which was founded in 1991 and was one of the first research centers dedicated solely to the study of AIDS, he led a team that pioneered the "hit 'em early and hit 'em hard" approach to drug therapy, now the core of the ARV-cocktail treatment that is keeping millions of HIV-positive patients alive. His lab showed...
...didn't take long before these futile efforts began to wear on the researchers in the field, not least of all those at ADARC, where Ho's group was attempting to develop its own vaccine - with little success. The center - which had earned such laurels for its ARV triumph - began to suffer a scientific slump and lack of direction, according to those who left in the early 2000s. Some blame Ho's management style, which, they say, changed in the aftermath of media attention that came with his recognition as Person of the Year. They describe a highly competitive atmosphere...