Word: folic
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Dates: during 1950-1959
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...within a year joined the surgical staff of Manhattan's Mount Sinai Hospital. He has been there ever since. Besides his historic work on citration, Dr. Lewisohn introduced more drastic (and proportionately more effective) operations for stomach ulcers, and pioneered in using the first crude preparations of folic-acid antagonists against cancer. Though technically retired, Dr. Lewisohn follows closely the war on cancer, still visits Mount Sinai's Cell Research Laboratory almost every...
...analogue (close chemical kin) to fill the metabolite's place but yield no nourishment. First to use antimetabolites this way was Dr. Sidney Farber of Boston Children's Hospital and the Children's Cancer Research Foundation. Knowing that leukemic cells are avid for the vitamin folic acid, he began in 1947 to treat child victims of acute leukemia with analogues of folic acid. Lederle Laboratories sent Dr. Farber two, aminopterin and amethopterin. which soon brought about improvement in most of the children. But after weeks or months, their disease became resistant...
...report for the New England Journal of Medicine Drs. Gajdusek and Zigas list the treatments they have tried: aspirin, sulfas, three antibiotics, cortisone, hydrocortisone, testosterone, phenobarbital, antihistamines, anti-epilepsy drugs, vitamin B, folic acid, liver extract and even a war-gas antidote, British Anti-Lewisite-all to no avail...
Magic Through Vitamins. Dr. Spies did much to prove the effectiveness of folic acid, another vitamin, in treating several forms of anemia, including early cases of pernicious anemia. Next, at the University of Havana's Calixto Garcia Hospital, he gave folic acid to victims of tropical sprue, a wasting, debilitating deficiency disease of which anemia is one symptom. Again, patients got better as though by magic. The burden of Spies's current work in Havana and San Juan: to defeat tropical sprue by prevention...
Back on the Farm. "Jimmy," for whom the clinic and research building was named, is a New England farm boy. When he first saw Dr. Farber, the diagnosis was dismal: lymph-node cancer. Previous results with nitrogen mustard had been spotty, so Jimmy got three (out of the seven) folic acid antagonists. Today he is back doing chores on the family farm and feeling fine. His cancer shows no sign of activity...