Word: folkman
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...There's a herd mentality," said Ted Folkman, a second-year law student who is applying at 12 private sector law firms in search of a summer job. "Everyone wants to know where everyone else is applying, and then they apply to those places too. It just adds to the stress...
...Folkman, who worked for the U.S. Attorney General's Office in Cleveland, Ohio last summer, says his job search has become more competitive this year as students vie for private sector internships that could turn into post-graduation job offers Stein's firm promises...
Armed with such knowledge, younger researchers think they can improve on Folkman's techniques. They prefer a more targeted approach: selectively attacking the various molecules and biochemical signals involved in building a new blood vessel. For instance, researchers at Ixsys, a biotech company in San Diego, have developed an artificial antibody that dissolves the biochemical glue that holds a tumor's capillaries together. Indeed, one of the patients in their safety study exceeded all expectations when two of the tumors in his abdomen shrank 70%. "I've been on the drug now for over a year," says Barry Riccio...
When Dr. Judah Folkman is asked whether he can cure cancer, he invariably replies, "Yes, in mice." That's not entirely self-effacing whimsy. Like every good researcher--and every responsible science journalist--he knows all too well that most drugs that work in lab animals turn out to be duds in humans. The field is littered with "magic bullets" that failed, among them monoclonal antibodies, tumor necrosis factor, interferon and interleukin-2. While all were initially hyped as potential cure-alls, they have turned out to have only modest usefulness in the war on cancer. At best, says...
...Harbor, Maine, the world's most famous mouse-breeding facility. Each year the lab ships out some 2 million mice from more than 1,700 stocks, including so-called designer mice with genes added or deleted so that they more closely "model" human disease. Among its customers is Folkman, whose lab relies on Jackson's best-selling C57BL/6J, or "Black 6" (cost: $8.15 to $10.85 apiece, depending...