Word: folkmans
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...cancer patient whose tumor is not responding to conventional therapy can go into clinical trials of new drugs, but there are sometimes waiting lists and shortages," Folkman says. "Whenever lab discoveries come close to application, you have to be super-extra careful...because media coverage can increase expectations...
Donald E. Ingber, an associate professor of pathology at HMS and a research associate in pathology and surgery at Children's Hospital, has worked with Folkman for 15 years and has had a front-row seat during the recent media events...
...media may be trivializing [Folkman's] contributions by putting all the pressure on one compound, endostatin, to be a silver bullet in the clinic. This is unfair," he says. "[Folkman's] contributions to both angiogenesis inhibitors and stimulators in clinical trials cannot be underestimated...
Ingber adds that to him it seems the media flurry surrounding endostatin trials and Folkman's recent work is attributable at least in part to the perceived novelty of the results...
...Ingber himself who, as a post-doctoral fellow, discovered the drug TNP-470, the first angiogenesis inhibitor from Folkman's lab to enter human clinical trials...