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...things are as terrifying as losing one's mind. Alzheimer's disease is the most common form of dementia among the elderly and affects as many as 4.5 million Americans, according to the U.S. National Institutes of Health. It currently has no cure. But recent research offers groundbreaking insight into what causes the disease, and how researchers could reduce people's risk. Walter Kukull, director of the U.S. National Alzheimer's Coordinating Center, explains...
...from genetics. There's a particular protein that's made in people with Alzheimer's - which is made from a protein that all of us make, the amyloid precursor protein. [In people with Alzheimer's] that precursor protein is clipped by enzymes in the wrong place, and begins to form these little toxic parts that aggregate [in the brain] and eventually form fibrils and plaques that are the main pathologic feature of Alzheimer's disease. It's not clear why this happens exactly, and a lot of people have been studying it pretty hard. It's also not clear...
Drug discovery work is going on right now, mostly in two directions. One is to block these enzymes that cut the precursor protein in the wrong place, so that the plaque-forming bits of the protein aren't formed. And the other is to think of ways, probably [having to do] with the immune response, to break up the aggregated protein bits once they do form...
...primaries, Florida presents one of his biggest challenges in the general election. His bond with Latino voters is tepid at best; the Jewish community was wary of Obama's commitment to Israel well before President Bush hurled last week's "appeasement" charges his way; Florida's elderly, particularly women, form a solid Clinton base, and PR problems like Reverend Jeremiah Wright and the elitist label remain a wall between Obama and many northern Floridians, especially in the state's conservative, blue-collar Panhandle...
...Spielberg movies are often about the separation and reconstituting of a family, and the last two Indy films are no exception. In Last Crusade we met Indy's father (Sean Connery) and learned that Indy's real name was Henry Jones, Jr. Indeed, "Junior" was Dad's apparently derogatory form of address for his son. That gag is repeated here, since - as everyone who's paid the slightest attention to pre-release scuttlebutt knows - Mutt is Indy's son by Marion. (Why is he called Mutt? Presumably because, as we learned at the end of The Last Crusade, Indiana...