Word: fragment
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Dates: during 2000-2009
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...that had eluded better-funded corporate researchers. In October 2002, Jhoti and his colleagues at Astex discovered in their Cambridge lab a chemical that bound to a protein called beta-secretase (Bace), which researchers had identified as a possible cause of Alzheimer's disease. The chemical was just a fragment of what could eventually become an Alzheimer's-conquering drug. But it represented a big step in the quest for a Bace-targeting substance, which drug giant AstraZeneca had been seeking for years; the firm enlisted Astex's help. "AstraZeneca worked on it for four years. We delivered an early...
...Astex calls its drug discovery method "fragment-based,'' because rather than throwing an entire proposed drug molecule at the target protein, they throw just pieces at a time. Jhoti claims this yields a much higher success rate than trying out whole molecules, an approach favored by large drug companies like the one he left in 1999, Glaxo Wellcome...
...roads or popped up in windows. The fight lasted nearly two hours. The young grunts defended themselves with all manner of fire, including AT4 antitank rockets, M-203 40-mm grenade launchers and TOW missiles from the Bradleys supporting them. A young sergeant went down, shrapnel or a bullet fragment lodging in his cheek. After checking himself, he went back to returning fire...
Another unimpressive display was just as arbitrary and unbefitting. This one involved a fragment of an old coaxial cable in a vitrine. The exhibition text argued that Evans believed the object to be a portion of the cable belonging to the phone used by Marcel Duchamp during his stay in the United States...
...Niuniu has just returned from the hospital where she's been diagnosed as "mentally disordered." Outside she sees a city bustling with new roads, new cars, new phones, new buildings?and filled with a compassionless new breed of people chasing material wealth. She is a self-proclaimed "fragment in a fragmented age," left to dwell on her own adolescence and wonder where it all went wrong...