Word: fragments
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...structure-based drug design, the three-dimensional structure of the designated biological target determines the components of the treatment while fragment-based approaches in drug discovery employ physical techniques to determine how fragments bind to protein targets...
Fesik highlighted the importance of fragment-based approaches and their advantages in the creation of new drugs...
...Fragment-based screening involves highly-focused chemistry,” he said. “It tailors molecules to bind to a protein target of interest and covers more chemical space, while identifying hits not obtained in other screens...
...trying to identify useful lead molecules and compounds in clinical trials,” he said. “My lab is focused on developing improvements in fragment-based approaches and applying them to target proteins involved in protein-protein interactions...
...team of archaeologists discovered a fossilized fragment of a pinkie finger in the secluded Denisova Cave in the Altai Mountains of Siberia. The finger was buried with bracelets and other artifacts typical of early human sites dating back about 35,000 years. It was sent to the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, for routine genetic analysis. When the results came back, Johannes Krause, a researcher at the institute, called his colleague Svante Pääbo on his cell phone. "You'd better sit down," he said. "The finger is not human." (See TIME's photo...