Word: friedman
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Dates: during 2000-2009
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...treatments will fail clinical trials. But doctors who treat the disease are experiencing a surge of optimism the likes of which they have never felt before. "It's no longer spin the wheel, let's try this drug, maybe it will work," says Henry Friedman, a neuro-oncologist at Duke University Medical Center. "We're going to know why a drug is or isn't working." And given the nature of cancer and the scientists who study it, if one approach doesn't fly, there will be no shortage of other ideas...
...regulation--and how the whole system can go awry. With that understanding, they believe, it may be possible to develop drugs that do the job balky genes fail to do--controlling a problem that decades of fad diets and self-help books have never solved. Says molecular biologist Jeffrey Friedman of the Howard Hughes Medical Institute at Rockefeller University in New York City: "Genomics will identify the players in this system, eventually leading to new targets and new treatments...
...discovery of leptin in 1994 that got the genetic study of obesity rolling, and it was Friedman's research team that was responsible. Studying the genome of a rare strain of hugely obese mice, the investigators found that all of them shared a defect in a gene that coded for a previously unknown hormone released by body fat. When a normal animal gains too much weight, the hormone signals the brain to turn down the appetite rheostat. When fat stores drop, the hormone is shut off, causing appetite to rebound. In the gene-damaged mice, there was no leptin...
...EMERGING TECH PARTNERS KEY OFFICERS: Wei-Wu He, William F. Snider, Emanuel J. Friedman FOUNDED: September 2000 FUND SIZE: $40 million WHAT IT DOES: Venture-capital fund that invests in local genomics firms...
...encomiums were overdone by a commentariat that praises freely only when it comes to bury. Gore went gently into that good night because, as New York Timesman Thomas Friedman put it, someone had "to take a bullet for the country...