Word: friedmanly
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...country where 1 in 3 adults is seriously overweight, the news carried by the journal Science last week--that Friedman and his colleagues at the Howard Hughes Medical Institute and New York City's Rockefeller University had discovered a magical potion that melts fat in a matter of weeks--resonated with unusual force. Momentarily, at least, it buoyed the spirits of millions of such lifelong dieters as Barbara Cady, a former teacher from Fairmont, West Virginia, and boosted the stock of Amgen, the biotechnical firm based in California that holds the license on the underlying technology. For if Cady...
...many people struggling mightily to keep their weight in check wouldn't trade places with the mice in Dr. Jeffrey Friedman's laboratory? Two weeks earlier, these roly-poly fur balls weighed three times as much as a mouse should, and they still couldn't stop snacking. After daily injections of a new hormone, however, the tubby rodents suddenly started consuming less food and burning more fat. They shed those excess ounces and trimmed 30% off their bloated size. Even better, their cholesterol readings fell, as did the high glucose levels that made them mildly diabetic. Virtually overnight, it seemed...
...Friedman picked up the challenge, applying new tools developed by the field of molecular genetics. The secret factor, he reasoned, must be produced by a gene that was defective in the obese mice. So he began to hunt for such a gene, the ob, or obese, gene. Sure enough, late last year, after eight years of effort, Friedman and his colleagues pinpointed the ob gene in both average-weight and obese mice. They then inserted the normal gene into bacterial cells, providing at long last detectable quantities of the protein they called leptin...
...injecting leptin into obese mice, three separate teams of researchers, including Friedman's, have confirmed that this protein is indeed the blood factor that makes fat mice thin. But they are still trying to puzzle out just how it works. Friedman, for one, believes leptin is almost certainly a hormone that travels through the bloodstream to act on the brain. In fact, it appears leptin may act in a feedback loop like the temperature sensor in a thermostat--or in this case a "fatstat"--to tell the body whether to turn metabolism and appetite up or down. Thus when leptin...
...frequently at odds with the top executives at Warner Bros. film division, Robert Daly and Terry Semel. Some speculate that Daly and Semel were not unhappy to see Fuchs -- the one company official assigned to respond publicly to Dole's attack -- aking all the corporate heat. When Robert Friedman, head of advertising and publicity for Warner Bros. films, was asked for a comment on Dole's speech, he interestingly passed the buck. "It's not a movie issue," he said. "It's more a music issue...