Word: fronted
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Dates: during 1930-1939
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...Front Lobe. The pituitary gland consists of three parts, two lobes and a narrow middle. In the smaller rear lobe, two hormones have been fairly well identified (alpha-hypophamine and beta-hypophamine), which appear respectively to influence uterine contractions and blood pressure. Biochemist James Bertram Collip of Montreal's McGill University discovered a hormone of the middle pituitary (appropriately called intermedia) which affects, though it does not exclusively control, the blood sugar level...
...hormones secreted by the larger front lobe make the pituitary the "master gland." Yet no one knows just what or how many hormones the front lobe secretes. The trouble is that-although a few front lobe hormones have been freed of all but small traces of impurities-a living body's response under test may be due not to the hormone tested but to an "impurity...
When these sources of confusion were less well understood than now, it was fashionable to attribute every pituitary reaction to a separate hormone. Riddle exposed some of these as "ghosts." He believes the number of definitely established front-lobe hormones to be small-five at most. These possible five are 1) thyrotropin, the thyroid-stimulator; 2) adrenotropin, which acts on the adrenals; 3) and 4), "FSH" and "LH" which affect the ovaries or testes; 5) prolactin...
...affection. This earned prolactin the nickname of "mother love" hormone. The implication of the discovery was that mother love, though doubtless fortified and colored in women by training and tradition has a physiological basis in a chemical substance-probably large protein molecules. (Dr. Riddle found that prolactin and other front-lobe hormones are disintegrated by trypsin, an enzyme which has the special property of "digesting" proteins...
Charting & Checking. The station at Cold Spring Harbor is a cluster of buildings beside a tranquil bay off Long Island Sound. There Dr. Riddle and his co-workers have painstakingly tested prolactin and other front-lobe hormones on normal animals, fasting animals, animals without pituitaries, without thyroids, without adrenals...