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...those in the U.S. of comparable size and location, requiring crowd-control techniques the company picked up from Disneyland. "That was the smartest move," says Kaplan. Why cinnamon buns? "The chewy and glutinous texture of the dough is a little bit like Japanese sticky rice cakes," says Minako Fujiwara, creator of a Cinnabon fan website...

Author: /time Magazine | Title: Global Briefing: May 7, 2001 | 5/7/2001 | See Source »

...Tetsoro Fujiwara, a Japanese researcher, began surfactant replacement therapy in infants, the results of which were reported in 1980. Fujiwara was able to achieve success in this therapy through the use of calf-lung surfactant administered as a liquid into the trachea...

Author: By Ivan Oransky, | Title: Helping to Fight Infant Respiratory Disease | 11/12/1991 | See Source »

...comes what may eventually be a simpler and cheaper solution. In the British medical journal Lancet, Pediatrician Tetsuro Fujiwara reports successfully using a strange concoction to coat the lungs of 15 newborns with HMD who were not responding to standard therapy. The ingredients: purified surfactant taken from cow lungs and organic compounds. Others have tried a similar approach, using totally synthetic surfactants. But such solutions seemed not to work because they lacked some essence of the natural substance. Moreover, no one had yet devised a way to apply a surfactant directly to a baby's lungs...

Author: /time Magazine | Title: Medicine: The Cow-Lung Concoction | 2/25/1980 | See Source »

...Fujiwara, an associate professor at the Akita University School of Medicine in northern Japan, solved these problems in a sort of medical hat trick that is, as he puts it, "simplicity itself." Picking up cow lungs at local slaughterhouses, he scraped off their surfactant, rid it of most of its protein, modified it with the organic compounds, and put the resulting white powder into solution. That way, with a tube and syringe, he could propel it directly into an infant's air passages. To spread it over the lungs, he just moved his tiny patients about until the alveolar...

Author: /time Magazine | Title: Medicine: The Cow-Lung Concoction | 2/25/1980 | See Source »

Some researchers have reacted cautiously to Fujiwara's announcement, warning that any long-range effects of using surfactant substitutes remain to be seen. They point out that scientists have not yet unraveled the chemical structure of natural surfactants and thus cannot tell if there is any significant difference between the human and animal variety. Fujiwara acknowledges that much testing remains to be done before the cow-lung concoction achieves widespread use. He plans a large-scale clinical trial of the substance this summer...

Author: /time Magazine | Title: Medicine: The Cow-Lung Concoction | 2/25/1980 | See Source »

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